Journal article
The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes
M Lappas
Placenta | W B SAUNDERS CO LTD | Published : 2014
Abstract
Introduction: Members of the NR4A subfamily are involved in a wide range of diseases including obesity and diabetes. The aim of this study was to determine the effect of maternal obesity and gestational diabetes mellitus (GDM) on the expression of the NR4A receptors Nurr1, Nur77 and NOR1. Methods: Human placenta was obtained at the time of term Caesarean section from (i) lean and obese and normal glucose tolerant (NGT) pregnant women; and (ii) women with GDM and BMI-matched NGT women (n = 16 patients). Primary trophoblast cells, isolated from human term placenta, were used to determine the effect of pro-inflammatory cytokines on NR4A protein expression. Primary trophoblast cells were also us..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr. Ratana Lim (Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne) is thanked for her assistance with the IHC and siRNA experiments. The clinical research midwives Genevieve Christophers, Debra Jinks, Rachel Murdoch and Gabrielle Pell, are gratefully acknowledged for assistance with sample collection. The Obstetrics and Midwifery staff of the Mercy Hospital for Women are also thanked for their co-operation. Funding: Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant no. 1047025). Additional funding was provided by the Medical Research Foundation for Women and Babies and the Mercy Research Foundation.